bcg疫苗7大著數2025!(持續更新)

目前正在進行臨牀試驗的減毒活疫苗包括VPM1002和MTBVAC。 VPM1002通過敲除MTB的某些毒性基因而獲得基因缺失突變株,可同時表達多種抗原並激活免疫反應。 2001年以來,大量臨牀試驗顯示,MTBVAC具有與BCG一樣的安全性,同時可誘導產生更好的免疫原性 [13-14] 。 此外,MTBVAC是目前進入新生兒預防性疫苗臨牀階段的唯一疫苗,其可誘導嬰幼兒產生持久的CD4細胞免疫應答反應,在嬰幼兒中具有替代BCG進行早期接種的潛力 [5,15-16] 。

  • 雖然臺灣的結核病盛行率逐年下降,但目前仍未降低至足以貿然取消施打卡介苗的接種。
  • Vaccae TM 是一種治療性疫苗,研究顯示,接種該疫苗並接受抗結核治療的耐多藥TB患者,6個月後的痰液陰轉率爲43%,遠高於僅接受藥物治療者(21%) [17] 。
  • 令人遺憾的是,在多種腫瘤的治療中,BCG很快就被更有效的治療所取代。
  • 通過尿道導管將120mgBCG注入50ml鹽水中,再灌注到膀胱內。

阿比工作到20世紀80年代才確認了疫苗的「非特異性效應」,但科學家們早就懷疑,當人類接種疫苗時,會發生一些奇怪的事。 事實上,麻疹在其它地方導致的兒童死亡率不足幾內亞比的一半。 根據最初死於該病的人數比例,疫苗的效果應該遠不如以前。 接種疫苗大約一年後,他們有了驚人的發現:接種過麻疹疫苗的人比未接種的人死亡率低50%。 「太令人震驚了,」阿比說,但原因並不像一開始想的那樣。

bcg疫苗: 膀胱癌電切術後注意事項_膀胱癌_膀胱癌日常注意事項 – 好大夫在線

4 至 6 週後會變成膿瘍或潰爛,不必擦藥或包紮,只要保持清潔及乾燥,如果有膿流出可用無菌紗布或棉花拭淨,應避免擠壓。 平均 2 至 3 個月會自動癒合結痂,留下一個淡紅色小疤痕,經過一段時間後會變膚色。 另外,若有特殊需求,例如出國,公費疫苗的項目也可以自費先施打,若不只一劑,之後在跟著公費的施打時程接著施打即可,也可以依照要去的國家自費施打其他特殊的疫苗。 公費除了掛號費跟檢查費之外,藥品費是 0 元,自費的藥品費則是 200 〜 5,000 元不等,無論是公費或自費,只要到有和政府合作的診所或是醫院、各地方衛生局就可以施打。

這些結果顯示rBCG1和rBCG2可誘導輔助型T細胞激素和MCP-1分泌,使巨噬細胞數量增加,並分化成殺菌力強的M1表現型,以清除肺部細菌,達到快速清除肺臟肉芽腫的病理現象。 與天花疫苗一樣,脊髓灰質炎疫苗也伴隨著大量的非特異性效果。 例如,2004年,儘管脊髓灰質炎在幾內亞比紹幾乎已經完全根除,但它在一定程度上降低了兒童死亡率約67%。

bcg疫苗: 膀胱癌一定要切除膀胱嗎?_膀胱癌_膀胱癌治療方式 – 好大夫在線

接受過疫苗治療的膀胱癌患者對阿爾茨海默氏症的易感程度較低,目前正在進行臨牀試驗,看看它是否能降低斑塊的發病率。 bcg疫苗2025 這些神祕的效應不僅能讓我們安全度過童年,還能降低生命中每個階段的死亡風險。 幾內亞比紹的研究發現,在接種天花疫苗時烙下傷疤的人中,80%更有可能在研究開始後三年依然存活,而在丹麥,科學家發現,童年時期接種結核病疫苗的人中,42%不太可能死於自然原因,直到他們到了45歲。 在狗身上也是如此:在南非進行的一項實驗發現,接種過狂犬病疫苗的狗存活率要高得多,遠遠超過了它們對狂犬病免疫的預期。 BCG疫苗可用於預防結核病,並且它們仍在世界大部分地區使用。 當BCG用作膀胱癌的免疫療法時,它通過導管放置在膀胱中。

bcg疫苗

這也許可以解釋為什麼疫苗還可以保護人們免受某些癌症和癡呆症的傷害,因為免疫系統在兩者發展中都扮演著重要角色。 我們的免疫細胞不斷在身體裏尋找突變的組織來破壞,而癌症在服用免疫抑製藥物的人身上明顯更常見。 與此同時,長期以來,揮之不去的炎症被認為與阿爾茨海默病有關,而阿爾茨海默病與克羅恩病等免疫狀況有關。 大規模試驗發現,疫苗接種將兒童的死亡率降低了三分之一(其他研究得出的估計數字要高得多),而其中只有4%的下降是因為疫苗預防了兒童感染麻疹。 患者需要告知醫療保健提供者病史,包括正在服用的任何處方藥或非處方藥。 目前,BCG僅在醫學上被批准用於治療膀胱癌,不適用於其他癌症類型。

bcg疫苗: 免疫治療卡介苗(BCG)對非肌肉浸潤性膀胱癌的治療作用

觀察家認為,率先推出疫苗對中國來說不僅意味著地緣政治影響力,更可緩解人們批評其早期掩蓋疫情的形象,因此習政權大力支持製藥公司,且讓國家力量介入共同研究,以掌握最後成果。 通俗的講,卡介苗治療膀胱癌的原理就是卡介苗通過某種方式激活患者的免疫系統,讓強化活躍的免疫細胞發揮抗腫瘤作用,從而降低腫瘤進展及復發風險。 卡介苗對纖維連接蛋白 大分子蛋白受體具有較高的親和力,當卡介苗與受損膀胱壁黏膜上的 FN 結合,機體免疫反應受到刺激活化,從而殺滅腫瘤細胞。

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” width=”603px” alt=”bcg疫苗”/>

因此想獲得針對所有人羣有保護作用的疫苗存在難度。 另一方面, bcg疫苗2025 NTM早期暴露會影響疫苗的免疫保護效果。 不同地理位置的人羣,早期NTM的暴露情況不同,同一種疫苗誘導的免疫保護作用不同。 因此,獲得針對不同地區均有保護作用的疫苗也存在難度。 以B淋巴細胞爲例,不同個體的B淋巴細胞在成熟過程中,編碼抗體抗原識別區的序列會隨機重組。 疫苗作爲外來抗原刺激B淋巴細胞發生克隆增殖的反應不同,因此誘導的免疫保護作用也不同。

bcg疫苗: 全球“最邪惡公司”的發展史:惡毒,隱瞞,死不悔改

而疑因接種臺灣檢驗或書面審查合格之疫苗疑似受害者,均可提出申請。 在接種疫苗後,如發生身體不適狀況,請先行就醫治療,就醫診斷後如懷疑為接種疫苗所引起,即可聯繫當地衛生局,申請「 預防接種受害救濟」,只要是經食藥署檢驗合格,不分公費或自費疫苗,均可申請。 接種疫苗後發生不適情況 bcg疫苗 (疑似不良反應),若症狀持續或加重情形,請立即就醫進行檢查及治療,並由醫護人員通報轄區衛 生局或撥打衛生福利部疾病管制署1922 專線。 近日韓國傳來多起因施打疫苗後的不良反應,更有至死的案例,而臺灣直至日共接獲76起不良反應通報,其中有1人於施打後得了罕病,雖全數都被證實和施打流感疫苗無關,但仍然讓民眾心裡有所顧忌。 衛福部表示,民眾因接種疫苗後引發不良反應,可跟政府申請「預防接種受害救濟」,送件後經由各界專家審議,覈定後最高可補助600萬救濟金,而覈定流程則為6個月。 以下為申請常見Q&A整理,讓民眾在3分鐘內可掌握相關補助訊息。

其可以防止約20%的孩子被感染,而疫苗可保護約一半已經受到感染的小孩病情不再惡化。 卡介苗是唯一採用皮內注射的疫苗(其他疫苗一般是肌肉注射或皮下注射)。 卡介苗是一種牛的分枝桿菌所製成的活性疫苗,經減毒後注入人體,可產生對結核病的抵抗力,一般對初期症候的預防效果約85%,主要可避免造成結核性腦膜炎等嚴重併發症。 bcg疫苗 結核病是感染結核桿菌所引起的疾病,結核菌侵入人體後,可在任何器官引起病變,如肺、腦膜、淋巴腺、骨骼、腸、泌尿及生殖器官等,其中以侵害肺部最多。 早期的肺結核病人沒有什麼症狀,容易被忽略而延誤治療的時間,如出現咳嗽、咳痰、食慾不振、體重減輕、長期發燒、夜間盜汗、咳血等症狀,可能是中度或重度肺結核了 。 Merck & Co., Inc., Rahway, NJ, USA 及其附屬公司。

bcg疫苗: 膀胱癌_第二療程卡介苗灌注,反應比較重_請問卡介苗灌注後反應比較大怎麼處理?有沒有緩解的藥物?還有灌注之前的一個星期,打了新冠疫苗,是否影響 – 好大夫在線專家團隊

此外,研究團隊測試rBCG1與rBCG2疫苗的安全性,於免疫缺陷(SCID)與C57BL/6野生小鼠注射了相同劑量的BCG與rBCG疫苗並記錄體重。 接種疫苗後,免疫缺陷與正常小鼠均未顯示任何不利的體徵。 顯示即使在免疫缺陷的個體中,rBCG1和rBCG2疫苗也是安全的。

bcg疫苗

1990年FDA批准BCG用於治療淺表性膀胱腫瘤。 距離首次報道40多年後的今天,BCG灌注治療仍然膀胱癌的標準治療方案。 1929年,Pearl在巴爾的摩約翰霍普金斯醫院進行的一項屍檢研究中報告,結核病患者的癌症發病率較低。 他檢查了死於各種惡性腫瘤的患者,並將其與癌症倖存者的年齡,性別和種族進行比對。

bcg疫苗: 預防接種

肺結核是全球十大死因之一,自2007年超越HIV/AIDS成為單一傳染病導致的主要死亡原因。 預防結核病的方法為注射卡介苗(Bacillus Calmette-Guerin, BCG),BCG是由減毒的牛結核分枝桿菌(Mycobacterium bovis)製備而成。 在兒童時期接種可提供10至15年的保護期,免疫力在成年後會減弱。 基於這些流行病學證據,BCG似乎隨著時間的流逝失去了保護作用。

打疫苗是保護自己也是保護他人,有些家長可能會覺得自己的孩子沒有打疫苗,還不是健健康康的沒有生病,但那其實是受到「羣體免疫」的保護,也就是很多人都有打,所以大家得病的機率都變低,還是非常建議家長帶孩子去打疫苗。 另外,建議家長帶寶寶去打疫苗的時候,除了要攜帶兒童健康手冊、健保卡,也要在接種疫苗之後,觀察寶寶是否有過度的不適,應立即告知醫師。 由於皮內劃痕可耐受120 mg,Morales認爲由於膀胱內停留1至2小時內尿液的稀釋作用,這種高劑量(120 mg)優於低劑量(60 mg)。 Morales選擇了由Institute Armand Frappier(Montreal)製造的疫苗。 免疫功能不全和HIV感染者爲BCG接種的禁忌症。 在宮內或通過哺乳暴露於免疫抑制治療的嬰兒也不應接種BCG疫苗。

bcg疫苗: 卡介苗的好處

由於皮內劃痕可耐受120 mg,Morales認爲由於膀胱內停留1至2小時內尿液的稀釋作用,這種高劑量優於低劑量。 另外,研究人員也意識到批次之間的菌落形成範圍也不盡相同。 選擇10例行膀胱腫瘤電切術後復發頻繁的患者進行BCG灌注治療。 灌注BCG後的膀胱組織活檢顯示出強烈的肉芽腫反應,其特徵在於壞死區域周圍多核鉅細胞、單核細胞和組織細胞的聚集。 Morales於1972年設計了針對膀胱腫瘤的原始BCG方案。 Morales選擇了由Institute Armand Frappier製造的疫苗。

bcg疫苗: 為什麼國民黨選擇與霸凌臺灣的中共「團結」而不是「我們」?

兒童作爲特殊羣體,免疫功能發育尚不完善,診斷和治療更爲困難,疫苗接種顯得尤爲重要。 BCG作爲現有疫苗,存在多種不足,新型疫苗研發是彌補這一不足的主要方式。 解決現有研發存在的問題、促進新型疫苗發展、提高疫苗保護率和安全性是未來疫苗研發的重中之重。 臺灣的疫苗政策已經算很完整了,每年衛生福利部國民健康署公佈的兒童健康手冊都會列出寶寶要打的疫苗。

國際上對卡介苗保護時間還未有共識,杜鴻運表示,過去很多國家都有研究,不過不同國家「做出來差異很大」,如挪威研究認為至少有40年,不過印度研究認為沒有保護力,後來不打。 臺灣新生兒雖有強制施打卡介苗,不過長大後保護力似乎不再。 杜鴻運說,若根據疾管署數據,純粹從流行病學來看,年齡層在15歲以後肺結核人數快速上升,推測臺灣卡介苗防護力可能只有15年,遇到肺結核還是會感染。

bcg疫苗: 膀胱癌電切術後16天。__幫我看下病理,治療方案,預後,後期複發率高不高,免疫組化指標代表什麼 -好大夫在線圖文問診

因此國家調整了脊灰的免疫程序,從口服糖丸過渡到針劑和口服滴劑,也就是我們常說的脊灰“1+3”、“2+2”免疫策略。 卡介苗、二價脊灰減毒活疫苗、麻腮風疫苗、麻疹疫苗、麻風疫苗、水痘疫苗、口服輪狀病毒疫苗、乙腦疫苗(也有滅活疫苗)、甲肝疫苗(也有滅活疫苗)等。 醫藥 「2019新型冠狀病毒」恐不會像SARS快閃,有潛力發展成有效的新興傳染病 新型冠狀病毒重症率及致死率雖比SARS低,但也更有機會在人體存活,發展成有效的「新興傳染疾病」,像流感一樣年年來,防疫恐須有長期抗戰的準備。 多媒體 從武漢到世界──COVID-19(武漢肺炎)疫情即時脈動 COVID-19(武漢肺炎)疫情發展瞬息萬變,《報導者》串接即時更新的病例資料庫,以多媒體地圖、圖表解釋疫情最新發展,更看見臺灣本土防疫和科研進展。 醫藥 【全球疫苗競速關鍵】8種疫苗比一比,臺灣競爭潛力在哪裡?

H4-IC31爲Ag85B-TB10.4融合蛋白,並加入了IC31。 研究發現,候選疫苗H4-IC31可誘導接種過BCG的嬰兒及青少年產生細胞免疫應答,進而發揮免疫保護作用,目前該疫苗已進入法國 Ⅱa期臨牀試驗 [27-28] bcg疫苗 。 H56是由MTB多階段抗原融合蛋白組成的亞單位疫苗,包含早期分泌蛋白Ag85B、ESAT-6和LTBI相關蛋白Rv2660c,相當於H1+ Rv2660c融合蛋白,目前進入丹麥 Ⅱa期臨牀試驗 [29] 。 卡介苗治療膀胱癌是人類治療腫瘤最成功的免疫療法。

bcg疫苗: 膀胱炎

活性減毒疫苗之間:可同時接種,如不同時接種最少要間隔4 週。 如為口服活性減毒疫苗則可與其他活性減毒注射式疫苗同時或間隔任何時間接種。 不活化疫苗與活性減毒疫苗:霍亂疫苗與黃熱病疫苗應間隔3週以上,其他可同時(分開不同部位接種)或間隔任何時間接種。 」在幾內亞比紹和丹麥,天花疫苗具有非常強的有益效果。

bcg疫苗: 寶寶非得打疫苗?張馨宇醫師:增加羣體保護力!

臺大醫院新竹分院小兒感染科醫師陳文發說明,卡介苗也稱為BCG疫苗,在結核病防治的歷史上扮演重要角色。 雖然對於防治一般肺結核疾病的效益差強人意,但對於嚴重的結核疾病,如散播性結核分枝桿菌感染與結核性腦膜炎,仍有防護成效。 臺灣的結核病盛行率確實逐年下降,但目前仍未降低至足以貿然取消卡介苗的接種。 另一種觀點認為,疫苗在無意中為免疫系統提供了更普遍的訓練。 最近的研究已經發現了支持這一觀點的證據,其中包括一項發現:一組接受卡介苗治療,然後暴露於結核以外病原體的年輕人與未接種疫苗的人產生了不同的免疫反應。

bcg疫苗: 寶寶疫苗如何聰明打?小兒科醫師這樣說…

膀胱中的活細菌改變了人的免疫反應並提高了他們抵抗癌症的能力。 這是今天仍然用於某些膀胱癌患者的BCG免疫療法類型。 過去科學家已經知道,卡介苗除了能預防結核菌感染,也能使多種病菌所引起的呼吸道感染降低許多。 20 世紀初歐洲大規模推行新生兒施打卡介苗後,新生兒死亡率降低許多,這並非單純預防結核病所致,研究發現體重過輕的新生兒死亡率也下降,推測可能是因為卡介苗活化幼兒免疫系統對抗其他入侵病菌的能力。 杜鴻運表示,過去調查發現,臺灣年輕人很多感染的結核桿菌是「北京株」,東南亞有打卡介苗的國家也發現,北京株感染率比較高。 國衛院正研發「重組卡介苗」,放入北京株特有的基因,也加入可增強免疫反應的細胞激素,希望在結核病上達到較好保護力,目前也已完成動物實驗,研究結果即將發表。

bcg疫苗: 膀胱癌 化療_膀胱癌 卡介苗灌注化療 膀胱癌 卡介苗灌注化療-好大夫在線電話問診

如果皮試結果爲陽性,醫生可能安排胸部 X 線檢查或 CT 掃描。 結果可能會顯示肺部有白色斑點,表示免疫系統已將 TB 菌隔開,或者可能顯示活動性結核病引起的肺部變化。 醫護人員會在 48 到 72 小時內檢查注射部位是否有腫脹。 如果出現堅硬凸起的紅色腫塊,表示您可能感染結核病。 早產兒和低出生體重兒——儘管證據有限,身體健康並且處於臨牀穩定狀態的中晚期早產兒(胎齡>31周)和低出生體重兒,可在出生時接種BCG,或者最晚推遲到從新生兒病房出院時接種。 其他低出生體重兒尤其是極低出生體重和超低出生體重嬰兒,將根據各自的臨牀病情評估決定疫苗接種的最佳時間點。

bcg疫苗: 新生兒結核病 (TB)

廣泛應用BCG數十年的國家,如印度和中國,結核病的盛行率並沒有因此而下降。 陳醫師進一步分析,卡介苗接種是有可能發生機率不高的嚴重不良反應,如卡介苗骨炎和骨髓炎,發生機率為百萬分之50左右。 過去觀察到卡介苗骨炎和骨髓炎的發生,可能跟出生早期接種卡介苗疫苗相關,因此自2016年1月1日起,卡介苗適合接種的年齡由出生24小時後及早接種,調整成出生後5至8個月接種,以期降低卡介苗骨炎和骨髓炎的發生。 至於輕微局部的不良反應,大部分都採取保守治療,可以持續觀察並定期回診,只有少數的寶寶需要使用細針抽吸膿瘍或使用抗結核藥物治療,大部分患者幾乎不必開刀。

結核病(tuberculosis,TB)是危害全球兒童健康的重要傳染病。 據2019年世界衛生組織(World Health Organization,WHO)估算,2018年全球約有1 000萬人罹患TB,124萬人因該病死亡,其中兒童TB新發人數約爲112萬,死亡數約爲17.3萬 bcg疫苗2025 [1] 。 與成人相比,兒童免疫功能發育尚不完善,自身抵禦TB的能力較弱,同時兒童TB病原學診斷困難、臨牀症狀不典型、藥物敏感性試驗陽性率低,更易延誤治療 [2] 。 因此,兒童TB負擔嚴峻,早期進行疫苗接種對於兒童TB的預防顯得更爲重要。 迄今爲止,卡介苗(Bacillus Calmette-Guerin,BCG)是全球唯一許可的用於預防TB的疫苗 [3-4] ,該疫苗自1921年研發至今,每年約有1億多兒童接種,佔全球每年出生兒童數的89% [5] 。

bcg疫苗: 膀胱癌術後複查_膀胱癌術後複查_膀胱癌 術後複查膀胱鏡 病理顯示尿路上皮原位癌 建議… – 好大夫在線圖文問診

灌注後,膀胱受藥液刺激可出現尿頻、尿急、血尿、排尿困難等症狀。 用於①腫瘤的輔助治療;②預防結核病;③治療哮喘性支氣管炎及預防小兒感冒。 也用於治療膀胱原位癌和預防復發,用於預防處於Ta或T1期的膀胱乳頭狀瘤經尿道切除術後的復發。 卡介苗(BCG Vaccine)是由減毒牛型結核桿菌懸浮液製成的活菌苗,具有增強巨噬細胞活性,加強巨噬細胞殺滅腫瘤細胞的能力,活化T淋巴細胞,增強機體細胞免疫的功能。 某些在妊娠期間暴露於結核病的孕婦可能在孕早期後或分娩後才接受異煙肼和維生素 B6,這取決於她們患上活動性結核病的風險。 患有活動性結核感染的新生兒可以聯用抗生素治療,包括異煙肼、利福平、吡嗪酰胺、乙硫異煙胺、乙胺丁醇和(有時)其他藥物。